The medicalization of the end of life has given rise to new situations and questions that are currently much debated, both in society and in ecclesial circles: medical aid in dying, withholding or withdrawing life-sustaining treatment, therapeutic obstinacy, living wills, palliative care, permanent vegetative states, etc. These questions, deeply marked by complexity and uncertainty, require clarification and deeper analysis. This seminar aims to reflect on the ethical, spiritual and theological issues encountered in end-of-life situations and to examine frameworks and landmarks for developing meaningful practices of moral discernment and spiritual and pastoral accompaniment.